nlmixr and ACoP7

21 October 2016

Occams is very proud to be playing a supporting role in the release of nlmixr, an open source package for population PK and PKPD modelling developed by Wenping Wang and Yuan Xiong. nlmixr builds on Wenping's RxODE package for simulation of nonlinear mixed effect models using ordinary differential equations, by implementing parameter estimation algorithms like nlme, gnlmm and SAEM. nlmixr greatly expands the utility of existing packages (like nlme) by providing an efficient and versatile way to specify pharmacometric models and dosing scenarios, with rapid execution due to compilation to C++.

The source is now available at along with a vignette, and the models and datasets used in the nlmixr/nlme poster to be presented at ACoP (W-66): nlmixr: an open-source package for pharmacometric modelling in R on Wednesday, 26 October, 2016, 7:30-9:30 am. At this point, nlmixr is still very much in a testing stage and is under lively development. Get in touch, see us at ACoP to discuss ways you could contribute (Wenping Wang, Yuan Xiong, Justin Wilkins and Rik Schoemaker will all be there), or try it out for yourself, and experience the joy of a population modelling package within R! A live demo will be possible, so come see Rik if you are interested!

WCoP 2016 and nlmixr

17 August 2016

Occams will be represented at WCoP 2016 in Brisbane by Rik Schoemaker. Meet him there or come see his poster on nlmixr: an open-source package for pharmacometric modelling in R on Monday, 22 August, 2016, 12.15-1:15 pm. nlmixr is a highly exciting open-source development that allows non-linear mixed effect modelling using R and the nlme package, but implementing full dosing flexibility along with ordinary differential equations, and computational speed by compling to C. A live demo will be possible, so come see Rik if you are interested!

Two new publications

27 July 2016

At Occams we believe in providing academic output next to our consultancy work, and we are therefore happy to announce that we have co-authored two publications over the last months:

Two oral presentations at PAGE

8 April 2016

We are extremely proud and honoured that Occams is has been granted two oral presentations at PAGE 2016! One will be presented by Lutz Harnisch (Pfizer) in a collaborative project with Pharmetheus, Occams and Pfizer with the title Modelling and simulation of neurological endpoints (modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to aid clinical trial design in intracerebral hemorrhage (ICH), and one will be presented by Rik Schoemaker (Occams) with the title Extrapolation of a Brivaracetam Exposure-Response Model from Adults to Children on work performed while at Exprimo in collaboration with UCB.

Healthy Birth, Growth and Development Hackathon

7 April 2016

The Bill & Melinda Gates Foundation is organising a Healthy Birth, Growth and Development Hackathon prior to PAGE, and Rik Schoemaker will be representing Occams. Will you join us? The networking reception from 6-9PM on Sunday 5 June is free for all! Sign up here.

Sponsorships in 2016

3 March 2016

Occams is committed to supporting global training, research and development in the field of pharmacometrics. Our consultants are variously associated with PAGE and the International Society of Pharmacometrics (ISoP), and in 2016 we are proud to be sponsors of PAGE (, WCoP ( and PMX Benelux !

...and then there were three!

16 November 2015

We are extremely proud and happy to announce to the world that the Occams team has been extended with both Janet Wade and Justin Wilkins!